Gluconeogenesis from L-lactate-2-T-2-C14in perfused rat liver
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چکیده
منابع مشابه
Gluconeogenesis from Lactate in Rat Hepatocytes
1. In freshly prepared isolated rat liver cells there is a lag in gluconeogenesis from lactate. The magnitude of the lag increases with increasing lactate concentration. 2. The lag is virtually abolished by lysine. 3. A few other amino acids (tyrosine, arginine, asparagine, ornithine) and NH4Cl had effects similar to, but less pronounced than, lysine during the early stage of incubation. Lysine...
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The role of mitochondrial anion exchange reactions in the control of gluconeogenesis in perfused livers from fasted rats was investigated by using Z-n-butylmalonate to inhibit malate transport across the mitochondrial membrane. Glucose production from pyruvate or lactate was inhibited 50% to 80% by 5 m&r butylmalonate. Oleate (0.5 or 1.5 mr+r) increased glucose production from pyruvate from 82 ...
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The uptake of propionate by the isolated perfused rat liver is not influenced by oleate or glucagon. However, glucagon does stimulate glucose production in the presence of 10 flwl propionate and increases the incorporation of isotope from [14C]propionate into glucose. These observations have been interpreted to indicate a sparing of the metabolism of propionate in the citric acid cycle by endog...
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1. Perfused rat livers were subjected to an acid perfusate and varying degrees of ischaemia in an attempt to simulate the conditions of strenuous exercise or shock. 2. Lactate uptake and glucose output from the liver decreased during moderate ischaemia alone and more so when, in addition, the perfusate was made acidic. 3. Hepatic ATP and ADP content increased in the presence of an acid perfusat...
متن کاملGluconeogenesis in the isolated perfused rat kidney.
The perfused rat kidney was used for a study of gluconeogenesis. The kidney was completely isolated and perfused with Krebs-Henseleit bicarbonate buffer containing 5% albumin. Perfusion flow rate and pressure remained stable for 2 to 3 hours, although the glomerular filtration rate diminished with time. The fractional reabsorption of both water and sodium was 0.92 during the 1st hour of perfusi...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1969
ISSN: 0014-5793
DOI: 10.1016/0014-5793(69)80189-4